B. Richardson
Mar 6, 2002
Citations
1
Influential Citations
35
Citations
Journal
JAMA
Abstract
Nonoxynol-9 has been used as a spermicide for more than half a century. The need for a female-controlled method for preventing acquisition of sexually transmitted infections (STIs) led to research into nonoxynol-9 as a vaginal microbicide. By the end of the 1980s several studies of the in vitro antimicrobial activity of nonoxynol-9 showed that it had the ability to inactivate various sexually transmitted pathogens including Neisseria gonorrhoeae Chlamydia trachomatis and human immunodeficiency virus type 1 (HIV-1). Animal studies conducted later seemed to confirm the results observed suggesting that nonoxynol-9 had high potential as an effective vaginal microbicide for prevention of STIs. (excerpt)