Yunzhi Li, A. Tong, Jing Huang
Apr 1, 2012
Citations
1
Influential Citations
27
Citations
Quality indicators
Journal
Chemistry & Biodiversity
Abstract
Two new cyclobutane‐type norlignans, methyl rel‐(1R,2S,3S)‐2‐(7‐methoxy‐1,3‐benzodioxol‐5‐yl)‐3‐(2,4,5‐trimethoxyphenyl)cyclobutanecarboxylate (1), and methyl rel‐(1R,2R,3S)‐2‐(7‐methoxy‐1,3‐benzodioxol‐5‐yl)‐3‐(2,4,5‐trimethoxyphenyl)cyclobutanecarboxylate (2), and a new lignanamide, 3‐hydroxy‐N‐[2‐(4‐hydroxyphenyl)ethyl]‐α‐[4‐(2‐{N‐[2‐(4‐hydroxyphenyl)ethyl]carbamoyl}ethenyl)‐3‐methoxyphenoxy]‐4‐methoxycinnamamide 4,8″‐ether (3), along with five known amides, 4–8, were obtained from the whole plant of Peperomia tetraphylla. Their structures were elucidated mainly by the analysis of NMR and MS data. The new compounds 1–3 and the known compound 4 were tested for their cytotoxic activities against the HepG2 (human hepatocarcinoma), A549 (human lung cancer), and HeLa (human cervical cancer) cell lines. Compound 4 showed significant cytotoxicity against HepG2 cell lines with an IC50 value of 9.4±1.0 μM.