Young Cho, S. Cha, D. Sok
1994
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Journal
Journal of Biochemistry and Molecular Biology
Abstract
Neurochemical effects of vemaculogen, a secondary fungal (Penicillium Verruculosum) metabolite were studied using rat synaptosomes. To evaluate the presynaptic effects of vemiculogen, high affinity uptake and potassium stimulated release, as well as spontaneous release of ³H-GABA from synaptosome enriched preparntions from the hippocampus, corpus striatum, and cerebrnl cortex were investigated. High affinity uptake of 3H-GABA into hippocampal and striatal synaptosomes decreased by 36.7 and 26.2%, respectively, in the presence of 0.1 mM vezruculogen, while ³H-GABA uptake in cerebrocortical synaptosomes showed no remarkable change. Vemiculogen had no significant effect on the spontaneous or the stimulated release of ³H-GABA from hippocampal, striatal, and cortical synaptosomes. These results suggest that verruculogen exerts presynaptic effects on GABAergic nerve terminals by inhibiting high affinity uptake systems in the hippocampus and striatum.