K. G. Feitsma, B. Drenth, R. A. Zeeuw
1988
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Abstract
Oxyphenonium bromide (Fig. 1) is a quaternary ammonium compound with strong anticholinergic properties. As with many other anticholinergics, the enantiomers of this drug exhibit large differences in therapeutic effects as well as in biliary and urinary excretion[1]. For a detailed study of the fate of oxyphenonium bromide enantiomers in the body, an assay is required that allows the simultaneous determination of the two enantiomers in the same sample. High performance liquid chromatographic (HPLC)-techniques are preferred, as quaternary ammonium compounds are very sensitive to decom-positon upon injection in GC.