F. Marsais, E. Bouley, G. Quéguiner*
May 29, 1979
Citations
0
Influential Citations
27
Citations
Journal
Journal of Organometallic Chemistry
Abstract
Abstract Butyllithium reacts with fluoroquinolines giving 1,2-addition products. This reaction leads to various fluorinated 2-butyl-1,2-dihydroquinolines which are substituted at the nitrogen atom. The addition of butyllithium is unavoidable even at low temperature and it hinders metallation reactions. However, we have succeeded in metallating fluoroquinolines by using lithium diisopropylamide, which is as reactive but less nucleophilic as butyllithium. This reaction is highly regioselective; satisfactory yields of metallated products are obtained.