Songnian Lin, M. Lombardo, Sunita Malkani
Jun 15, 2009
Citations
3
Influential Citations
20
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
Novel 1-(2-aminopyrazin-3-yl)methyl-2-thioureas are described as inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). These compounds demonstrate potent in vitro activity against the enzyme with IC(50) values as low as 15 nM, and suppress expression of TNFalpha in THP-1 cells and in vivo in an acute inflammation model in mice. The synthesis, structure-activity relationship (SAR), and biological evaluation of these compounds are discussed.