J. Clitherow, P. Beswick, W. Irving
Apr 9, 1996
Citations
1
Influential Citations
86
Citations
Quality indicators
Journal
Bioorganic & Medicinal Chemistry Letters
Abstract
Abstract Replacement of the isothiourea moiety of known histamine H 3 antagonists by certain 5-membered heteroaromatic systems can give compounds with an improved activity profile. One of these, 3-[(4-chlorophenyl)methyl]-5-[2-(1H-imidazol-4-yl)ethyl] 1,2,4-oxadiazole (GR175737) is a potent, selective, orally active and centally penetrating H 3 antagonist.