Albert W. Lutz and, Trotto Susan Hensen
Jun 1, 1972
Citations
0
Influential Citations
15
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
Ethyl 3-amino-4,4,4-trifluorocrotonate (3) has been converted by a one step reaction with alkyl and aryl isocyanates to novel 3-substituted-6-(trifluoromethyI)uracils. Also several 3-amino-4,4,4-trifluorocrotonitriles (11a-c) have been cyclized to novel 6-(trifluoromethyI)cytosines (13a-c) and then hydrolyzed to the corresponding uracils (4, 14b-c). Alkylation studies with isopropyl bromide of three 6-(trifluoromethyl)uracils (1, 4, 5) are described.