E. Naydenova, M. Topashka-Ancheva, P. Todorov
Apr 1, 2006
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0
Influential Citations
24
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Journal
Bioorganic & Medicinal Chemistry
Abstract
Abstract Novel α-aminophosphonic acids are synthesized reacting 1,3-oxazolidin-2-one derivatives with formaldehyde and phosphorus trichloride. Treatment of N -(phosphonomethyl)oxazolidinones with aqueous NaOH gave the expected α-aminophosphonic acids. The oxidation of (2-hydroxy-1,1-dimethylethylamino)methyl phosphonic acid in the presence of CdO and water resulted in N -phosphonomethyl-2-methyl-1-propanoic acid. Their structures were proved by means of IR, 1 H, 13 C, and 31 P NMR spectroscopy. The genotoxic, clastogenic, and antiproliferative effects of newly synthesized original aminophosphonic acids were investigated for the first time.