Jin-Hun Park, Jeong-Soo Chang, M. El‐Gamal
Oct 1, 2010
Citations
0
Influential Citations
15
Citations
Quality indicators
Journal
Bioorganic & medicinal chemistry letters
Abstract
Synthesis of novel amides and esters prodrugs of olmesartan is described. Their in vitro stability in rat plasma was tested. The results showed that the ester derivative IIa with n-octyl substituted dioxolone moiety was rapidly converted into olmesartan within 30 min. The pharmacokinetic parameters of IIa were studied and compared with those of olmesartan medoxomil. Compound IIa is proposed to be a promising prodrug of olmesartan.