R. Dickinson, A. Bell, C. Hitchcock
Aug 20, 1996
Citations
0
Influential Citations
64
Citations
Journal
Bioorganic & Medicinal Chemistry Letters
Abstract
Abstract Replacement of one triazole ring of fluconazole with 4-pyridinyl leads to an increase in activity against Aspergillus fumigatus. Introduction of an α-methyl group has a marked additional beneficial effect. Investigation of pyridinyl and pyrimidinyl analogues resulted in the identification of 30 (UK-109, 496, voriconazole) which has excellent potency against a broad range of fungal pathogens including A. fumigatus and Candida krusei.