J. Vanden Eynde, A. Mayence, Tien L. Huang
Sep 6, 2004
Citations
1
Influential Citations
22
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
A series of pentamidine congeners has been synthesized and screened for their in vitro activity against Pneumocystis carinii. Among the tested compounds, bisbenzamidines linked by a flexible pentanediamide or hexanediamide chain (7 and 9) emerged as exceptionally potent agents that were more effective and less toxic than pentamidine in the assays described in this study.