Bo Liu, Gang Liu, Zhili Xin
Oct 18, 2004
Citations
0
Influential Citations
27
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
Novel isoxazole carboxamides have been identified as growth hormone secretagogue receptor (GHS-R) antagonists. Substituent modification off the 5-position of the isoxazole ring led to analogues with potent binding affinity and functional antagonism of GHS-R. A potent analogue (32) with high aqueous solubility and good GPCR selectivity was also identified as a potential pharmacological tool for in vivo studies.