Hélène Chachignon, Mayaka Maeno, Hiroya Kondo
Apr 28, 2016
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Influential Citations
92
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Quality indicators
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Organic letters
Abstract
The regioselective trifluoromethylthiolation of indole derivatives was achieved under reductive conditions with trifluoromethanesulfonyl chloride as the readily available source of electrophilic SCF3 and a phosphine as the reducing agent. It is a straightforward process free from any metal and also applicable for the trifluoromethylthiolation of other azaarenes, enamines, and enoxysilanes.