Guobin Zhou, Yue-Qing Guan, Chao Shen
Jun 11, 2008
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Influential Citations
14
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Journal
Synthesis
Abstract
A novel and convenient synthetic approach for the preparation of thiazol-2(3 H)-imine-linked glycoconjugates, which involves the cyclization of 1-benzoyl-3-(2,3,4,6-tetra- O-pivaloyl-β- D-glucopyranosyl)thiourea with a variety of carbonyl compounds bearing an α-H in the presence of [hydroxy(tosyloxy)iodo]benzene (HTIB) and triethylamine, has been developed. The methodology has advantages such as avoiding the use of lachrymatory and toxic bromine, simplicity of procedure, mild reaction conditions, and high yields.