Bonnie A. McNeil, S. Zimmerly
Jun 1, 2014
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Journal
RNA
Abstract
A group II intron of Clostridium tetani alternatively splices in vivo to produce five distinct coding mRNAs. Accurate fusion of upstream and downstream reading frames requires a shifted 5′ splice site that is achieved by several structural elements (IBS1–EBS1, the GUGYG motif) and involves the 3′ exon recognition. The evolved novel ribozyme properties illustrate the plasticity of group II introns underlying the adaptation of new structurally based catalytic properties.