Temitope O. Olomola, Salerwe Mosebi, Rosalyn Klein
Dec 1, 2014
Citations
1
Influential Citations
28
Citations
Journal
Bioorganic chemistry
Abstract
A series of seven novel, rationally designed N-substituted 3-{3,5-dimethylfuro[3,2-g]coumarin-6-yl}propanamides have been prepared as potential HIV-1 integrase (IN) inhibitors via a five-step pathway commencing with resorcinol and diethyl 2-acetylglutarate, and the HIV-1 IN inhibition potential of these compounds has been examined relative to raltegravir, a known HIV-1 IN inhibitor.