M. Massa, D. Spangler, R. C. Durley
Jul 9, 2001
Citations
0
Influential Citations
46
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
A series of novel N,N-disubstituted trifluoro-3-amino-2-propanols has been prepared as potent inhibitors of cholesteryl ester transfer protein (CETP). Modifying the aromatic 3-tetrafluoroethoxy group in the lead molecule 1a with various heteroaryl moieties produced new 2-furyl analogues 2a,b with submicromolar potency in vitro.