P. Buckland
Mar 1, 1980
Citations
0
Influential Citations
3
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
A three step synthesis of 3-aminopyrazine-2-carboxylic acid (1) starting from pyrazine-2,3-dicarboxylic acid (5) is described. Diacid 5 is converted via the anhydride 6 into the ammonium salt of the half acid amide 7 which on Hofmann rearrangement gives the title compound in 55% overall yield.