Keiji. Yamamoto, K. Tsuruoka, J. Tsuji*
Sep 5, 1977
Citations
0
Influential Citations
8
Citations
Journal
Chemistry Letters
Abstract
Kinetic resolution was observed when (±)-2-dimethylaminopropiophenone was allowed to react with one-half equivalent of diphenylsilane in the presence of rhodium(I)-(−)-DIOP as catalyst. The recovered amino ketone was found to be (R)-(+)-enantiomer of 23% optical purity, while asymmetrically hydrosilylated products, after hydrolysis, were (1S, 2S)-(+)-pseudomethylephedrine and (1R, 2S)-(−)-methylephedrine in 27% and 20% ee, respectively.