V. Britsun, M. Lozinskii
Jun 1, 2001
Citations
0
Influential Citations
5
Citations
Journal
Chemistry of Heterocyclic Compounds
Abstract
2-Mercapto-3,4,5,6-tetrahydropyrimidine (1) is the starting reagent for synthesis of condensed nitrogenand sulfur-containing heterosystems which exhibit various types of physiological activity, such as bactericidal [1], fungicidal [2], and antitumor [3] activity. We propose a novel method for synthesis of a difficultly accessible heterocyclic system that has been little studied, 2-aryl-2,3,7,8-tetrahydro-4H,6H-pyrimido[2,1-b]-1,3-thiazin-4-one (2a-c), by reaction of 2-mercapto-3,4,5,6-tetrahydropyrimidine 1 with cinnamoyl chloride (3a) and its substituted 3b and 3c. In this case, the reaction products are obtained as the hydrochlorides.