Oana Moldovan, K. Albert, Iulia Nagy
Dec 21, 2016
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Journal
Tetrahedron Letters
Abstract
Starting from (1S,2S)-2-amino-1-(4-nitrophenyl)propane-1,3-diol (p-nitrophenylserinol, a waste optical antipode product from chloromycetin production) or its 5-amino-1,3-dioxane derivatives, we report preliminary data concerning the conversion of these optically active substrates into novel N-modified glycines by chemoselective N-monoalkylation with haloacetic ester or acid (X-CH2COOR, X: Cl, Br; R: Et, H) reagents. The results are discussed in terms of the starting material nature (cyclic vs. acyclic), the steric hindrance in the C-substituted 5-amino-1,3-dioxanes determining the reactivity of the amino-group and the stability of the intermediates. The synthesis of the first tripodands incorporating N-modified glycine motifs as peripheral units is also reported.