W. Dolbier, Jian-Xin Duan, Alex J. Roche
Jun 1, 2000
Citations
0
Influential Citations
30
Citations
Journal
Organic letters
Abstract
A novel synthesis of octafluoro[2.2]paracyclophane (AF4), one that remarkably does not require the use of high dilution methodology, is presented. Using this unprecedented methodology, AF4 is produced in 60% yield in a reaction of Zn with 0.35 M p-bis(chlorodifluoromethyl)benzene in DMA at 100 degrees C. The process comprises a convenient, inexpensive, and highly scaleable preparation of AF4 for both research and commercial purposes.