Yuefen Zhou, Lian-Sheng Li, P. Dragovich
Feb 15, 2008
Citations
1
Influential Citations
30
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
5-Hydroxy-3(2H)-pyridazinone derivatives were investigated as inhibitors of genotype 1 HCV NS5B polymerase. The structure-activity relationship (SAR) associated with variation of the pyridazinone 2- and 6-substituents is discussed. The synthesis and metabolic stability of this new class of compounds are also described.