K. Sadek, Laila Jaraph-Alhadad, R. Mekheimer
Nov 16, 2023
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Journal
Arkivoc
Abstract
1,3,5-Triazine derivatives are an important class of heterocyclic compounds with great interest in medicine, agriculture, electronics, and other industries. In this article, we report on the synthesis of 4-aryl-6-alkylamino/piperidinyl-1,3,5-triazine-2-amines via one-pot, multi-component reactions of cyanamide, aromatic aldehydes and an amine (piperidine, aqueous dimethylamine and butylamine) using microwave irradiation under neat conditions. The structure of the obtained products was confirmed by 1 H-NMR and 13 C-NMR spectra, mass spectrometry and, in two cases, X-ray diffraction.