Y. Xin
2000
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Journal
Journal of East China University of Science and Technology
Abstract
In search for more reasonable process for preparation of polyfluorated quinolone antibacterial agents, temafloxacin hydrochloride is prepared from ethyl 2,4 dichloro 5 fluorobenzoylacetate, via condensation, amination, cyclization, boron esterification, substitution, hydrolysis and salt formation with 45% overall yield. The structure of temafloxacin hydrochloride is confirmed by MS, 1H NMR, IR and EA.