Liu Ai-ju
2015
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Journal
Chinese Journal of Synthetic Chemistry
Abstract
Methyl 2-chloro-5-(ethoxycarbonylamino) benzoate(3) was obtained by reduction and condensation reaction using methyl 2-chloro-5-nitrobenzoate as the material.Butafenacil in total yield of 55.2% with 99.1% purity was synthesized by cyclization reaction of 3 with(Z)-ethyl 3-amino-4,4,4-trifluorobut-2-enoate,and then through methylation,hydrolysis,acylation and consideration.The structures of products and intermediates were confirmed by1 H NMR and EI-MS.