V. Krasnov, V. Zarubaev, D. Gruzdev
Apr 1, 2021
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Journal
Chemistry of Heterocyclic Compounds
Abstract
A number of novel amides were synthesized by coupling of 6-[(9 H -purin-6-yl)amino]hexanoic acid to heterocyclic amines. The antiviral activity of the obtained compounds, as well as of purine conjugates in which 7,8-difluoro-3-methyl-3,4-dihydro-2 H -1,4-benzoxazine is linked to position 6 of purine through a fragment of ω-amino acids with varying lengths of polymethylene chains against influenza A and B viruses was studied in vitro . Purine derivatives have been shown to have moderate activity against influenza A (H1N1) virus. The antiinfluenza activity and cytotoxicity of conjugates with 7,8-difluoro-3-methyl-3,4-dihydro-2 H -1,4-benzoxazine depend on the length of the linker fragment.