Chao Han, Ya-Zhuo Guo, Dandan Wang
May 1, 2015
Citations
0
Influential Citations
16
Citations
Quality indicators
Journal
Chinese Chemical Letters
Abstract
Abstract A series of novel pyrazole fused heterocyclic derivatives were synthesized via a two-step procedure or a one-pot two step method, and their catalytic DNA cleavage abilities and anti-BVDV activities were also evaluated. The results obtained indicated that compounds 3b – 3c could catalyze the cleavage of supercoiled DNA (pUC 19 plasmid DNA) to nicked DNA under physiological conditions with high yields via a hydrolytic mechanism. The studies on anti-viral activities against bovine viral diarrhea virus (BVDV) demonstrated that some of the pyrazole derivatives showed pronounced anti-BVDV activity with interesting EC 50 values and no significant cytotoxicity. Among them, compound 3l showed the highest antiviral activity (EC 50 = 0.12 μmol/L) and was 10 fold more than that of the positive control ribavirin (EC 50 = 1.3 μmol/L), which provided a potential candidate for the development of anti-BVDV agents.