Hirota, Kosaku, Sajiki
Jun 30, 1991
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16
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Abstract
The reaction of 5-cyanouracils with thioureas and guanidines causes novel pyrimidine-to-pyrimidine ring transformations. Thus, 1,3-disubstituted 5-cyanouracils (1) react with thiourea and guanidines to give the corresponding 5-carbamoyl-2-thiocytosines (2) and 2,4-diamino-5-carbamoylpyrimidines (5), respectively. On the other hand, 5-cyanouracils (8) possessing a phenyl group at the 1-position react with thioureas to give 7-aminopyrimido[4,5-d]pyrimidine-2,4-diones (9).