R. Ramanujam, Savita S. Ganjihal, N. Kalyanam
Jun 15, 2013
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Journal
Tetrahedron-asymmetry
Abstract
Abstract The synthesis of chemically and enantiomerically pure (S)-3-amino tetrahydrofuran hydrochloride starting from the natural amino acids, l -aspartic acid or l -methionine is described. The process involves no chromatography and can be easily carried out on a large scale. The enantiopurity of the final product was established by NMR and chiral HPLC methods.