Anshu Chaydhary, A. Singh, Prabhakar Kumarverma
Apr 16, 2015
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Abstract
A series of compound 6-bromo-3-(6-substitutedphenyl)-2-(morpholinomethylamino) pyrimidin-4-yl)-2H-chromen-2-one ( BT 1 M-T 10 M ), 3(2-((piperidin-1-yl) methylamino)-6- (2-substitutedphenyl) pyrimidin-4-yl)-6-bromo-2 H -chromen-2-one ( BT 1 P-BT 10 P ) has been synthesized from 3-(2-amino-6 -pyrimidin- 4-yl)-6- bromo- 2H-chromen-2-one ( T 1 -T 10 ). The structures of the synthesized compounds were elucidated by I.R., 1 HNMR, elemental analysis and mass spectroscopic techniques. The synthesized compounds were screened for in-vivo anti-inflammatory activity at a dose of 50 mg/kg body weight by a carrageenan-induced rat paw edema method. Among them, compounds BT 8 M , BT 4 P , BT 5 P , and BT 7 P exhibited significant anti-inflammatory activity. Compounds BT 3 M , BT 9 M , BT 10 M , BT 9 P , and BT 10 P showed highly significant anti-inflammatory activity. The remaining compounds showed less anti-inflammatory activity, comparable to that of standard drug diclofenac sodium.