H. Ong, M. Agnew
Jan 17, 1981
Citations
0
Influential Citations
9
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
A series of 2-aryl-2,3-dihydropsiro[benzofuran-3,4′-piperidines] has been synthesized as potential psychotropic agents via an efficient intramolecular fluorine displacement reaction. Treatment of a key intermediate, 4-cyano-4-(2-fluorophenyl)-1-methylpiperidine (2), with a large excess of phenylmagnesium bromide in refluxing tetrahydrofuran led to some 2-arylspiro[3H-indole-3,4′-piperidine] derivatives, 10 and 11, whose structures are elucidated on the basis of chemical and spectral evidence.