A. S. Pawar, S. Chattopadhyay, A. Chattopadhyay
Dec 1, 1993
Citations
0
Influential Citations
9
Citations
Journal
Journal of Organic Chemistry
Abstract
C-alkylation of 4-pentyn-1-ol (1) with 1-bromo-5-(tetrahydro- pyranyloxy)pentane, subsequent cis-hydrogenation, and PDC oxidation gave the C 10 aldehyde 10-(tetrahydropyranyloxy)dec-4-en-1-al (5). Its Wittig-Horner olefination, base-catalyzed deconjugation to the corresponding (3Z) compound, and enzymatic macrolactonization furnished (3Z,6Z)-dodecadienolide (I)