Noriaki Kudo, Satoru Furuta, Kazuo Sato
1996
Citations
0
Influential Citations
2
Citations
Journal
Chemical & Pharmaceutical Bulletin
Abstract
The reaction of methyl 2-chloro-5-ethoxycarbonylamino-4-fluorobenzoate (4a) and 1-bromo-3,3-dimethyl-2-butanone (2) in the presence of 2.2 eq of lithium bis(trimethylsilyl)amide afforded the 4H-1,4-benzoxazine (6a) in good yield instead of the expected 4-oxazolin-2-one (5a). The generality of the reaction and the mechanism are discussed.