Khadiga AbuZied Sharifa AbuBakr Mahmoud Youns Amel Hashim, Hoda ElDiwani
Nov 3, 2014
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Abstract
As a continuation to our previous work concerning anti-tumour activity of benzimidazole we have synthesized series of new derivatives of 2-(1H-benzimidazol-2-yl)-N-(substituted)hydrazine- carbothioamide (25), ethyl [2-(1H-benzimidazol-2-yl)-1- (phenylcarbamoyl) hydrazinyl]acetate(6), 2-[2-(1H-benzimidazol-2yl)hydrazinylidene]-3-benzyl-1,3-thiazolidin-4-one(7), 1,2-dihydro-3H-[1,2,4]tria-zolo[4,3-a]benzimidazole-3thione(8), 2,2'-(1,4-dioxido-1,4,2,3,5,6-dithiatetrazinane-2,6-diyl)bis- (1H-benzimidazole)dihydrochloric acid(9), 2,10-dihydro[1,2,4]triazino[4,3-a]benzimidazol-4(3H)-one(10), 1-[2-(1H-benzimidazol-2-yl)hydrazinyl]propan-2one (11), 4-[2-(1H-benzimidazol-2-yl)hydrazinyl]-4-hydroxybut-3-en-2-one (12),N'-(1H-benzimidazol-2-yl)-2chloroacetohydrazide (13), and 5-[2-(1H-benzimidazol-2-yl)hydrazinyl]-1,6-dihydro-1,2,4-triazine-3(2H)-thione (14). The anti-tumor effect of compounds 2-6,8-13, and14 was studied against breast cancer (MCF7) and compound 3[IC50=3.241μM] was found to be more active than doxorubicin (IC50 = 17.12μM).