S. Atsuumi, Chinatsu Ikeura, T. Honma
Oct 15, 1994
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0
Influential Citations
1
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Journal
Chemical & Pharmaceutical Bulletin
Abstract
A dihydroxyethylene isostere, (2S, 3R, 4S)-4-amino-5-cyclohexyl-1-morpholino-2, 3-pentanediol (ACMP, 1), which is a component of non-peptidic, orally active, low-molecular-weight renin inhibitors, was synthesized stereospecifically starting from 3-cyclohexyl-L-alanine via iodo-cyclocarbamation as the key reaction.