W. Chia, S. Shen, Hong‐Cheu Lin
Mar 11, 2001
Citations
0
Influential Citations
13
Citations
Journal
Tetrahedron Letters
Abstract
Abstract This study describes a novel and efficient synthesis of pyridine-containing liquid crystalline 5-substituted 2-(4-alkylphenyl)pyridines. 4-Alkylphenylmagnesium bromide was reacted with 3-substituted N -ethoxycarbonylpyridinium chloride to give regioselective 1,2-dihydropyridine intermediates, which were subsequently oxidized by o -chloranil. Good yields and high α-regioselectivity on the pyridine ring were observed in all cases.