Du Xiao-hua
2013
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Journal
Modern Agrochemicals
Abstract
2-Chloro-N,N-dimethylnicotinamide is an important synthesis intermediate.A novel synthetic route of the title compound was studied.Using propargyl alcohol and dipropylamine as the starting materials,3-dipropylaminoacrolein was obtained by catalytic oxidization,followed by a Knoevenagel condensation with 2-cyano-N,N-dimethylacetamide and a cyclization with hydrochloride to give the title compound.The total yield was more than 65% and the purity of the product was above 99%.The new method had such advantages as readily available raw materials,simple operations,mild reaction conditions and less wastes.It was valuable to be used in industrial scale.