Li Lai-cai
2013
Citations
0
Influential Citations
0
Citations
Journal
Journal of Sichuan Normal University
Abstract
The safety of food and drug attracts more and more attention,α-(2,4-diaminopyrimidin-5-yl)(3,4,5-trimethoxyphenyl) methanol has been also attracting the focus,because it is obtained in the production of trimethoprim which is an important sulfonamide synergist.A novel method for synthesis of α-(2,4-diaminopyrimidin-5-yl)(3,4,5-trimethoxyphenyl) methanol was reported.The target compound was successfully prepared via oxidation and subsequent reduction starting from trimethoprim.The overall yield was 66%.The structures of intermediates and final product were determined by LC-MS,1H NMR、13C NMR or IR techniques,which are in agreement with density functional calculations.