C. Xue, W. DeGrado
Jan 2, 1995
Citations
0
Influential Citations
17
Citations
Journal
Tetrahedron Letters
Abstract
Nα-Boc-Nα-methyl-Nω,ω′-bis(benzyloxycarbonyl)-L-arginine and Nα-Boc-Nα-methyl-Nδ-benzyloxycarbonyl-L-ornithine have been synthesized starting with Boc-L-Gln. The γ-carboxamide of Boc-L-Gln was dehydrated to a nitrile group and the resulting compound is selectively methylated providing N-Boc-2-methylamino-4-cyanobutyric acid. The nitrile is then reduced to an amine furnishing the key intermediate Nα-Boc-Nα-methyl-L-ornithine.