Wang Jian-hui
2011
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Journal
Chemistry & Bioengineering
Abstract
In this paper,acetanilide was synthesized from phenylamine and ammonium chloride with N,N-dimethylacetamide(DMAc) as acylation agent.The effects of reaction temperature and reactant ratio on the yield were investigated.And the optimum reaction conditions were obtained as follows:the molar ratio of ammonium chloride to phenylamine was 2∶1,the reaction temperature was 166 ℃,the refluxing reaction time was 3 h.Under above reaction conditions,the yield reached 98.0%.Compared with the traditional preparation methods of acetanilide,this method was simple in operation and after-treatment with high yield,so it was more suitable for industrial production.