A. Abdel-fattah, M. M. Elsayed
Oct 31, 2009
Citations
0
Influential Citations
8
Citations
Journal
Current Organic Chemistry
Abstract
3,3'-Benzene-1,4-diylbis(1-phenylprop-2-en-1-one) 3 reacted with 2- cyanoethanethio-amide 4 to afford the corresponding 4,4'-benzene-1,4- diylbis(6-phenyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile) 5. The synthetic potentiality of compound 5 was investigated in the present study via its reactions with several active-hydrogen containing compounds 6a-f aiming to synthesize 4-(3-amino-6-phenylthieno[2,3-b]-pyridine-4-yl)phenyl- 3-amino-6-phenylthieno[2,3-b]pyridine derivatives 8a-f directly in case of 8d,e,f,h and via 4-{4-(3-cyano-2-(alkylthio)-6-phenylpyridin-4-yl)phenyl}- 2-(alkylthio)-6-phenylpyridine-3-carbonitrile derivatives 7a-c,g in case of 8a-c,g. The structures of all the newly synthesized heterocyclic compounds were elucidated by considering the data of IR, 1H NMR, mass spectra as well as that of elemental analyses. Anti-cancer activities for all the newly synthesized heterocyclic compounds were investigated.