Guo Hong-yun
2008
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0
Influential Citations
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Journal
Fine Chemical Intermediates
Abstract
Gemcitabine hydrochloride was an anti-metabolic and anti-tumour nucleoside drug.A method to produce gemcitabine hydrochloride was devoloped from 2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate through reduction,p-toluenesulfonation,glycosylation with cytosine deprotection,salt formation and separative crystallization.The total yield of the target compound reached 14.8%.