N. S. Devi, S. Perumal
Jun 19, 2006
Citations
0
Influential Citations
21
Citations
Journal
Tetrahedron
Abstract
Abstract The four-component reaction of ethyl 4-chloroacetoacetate with aromatic aldehydes and ammonium acetate in a 1:2:1 molar ratio provided a simple and rapid access to highly functionalised pyrrolidines, ethyl 1-acetyl-4-hydroxy-5-[hydroxy(aryl)methyl]-2-aryl-2,3-dihydro-1 H -pyrrole-3-carboxylates stereoselectively. This transformation presumably occurs via a tandem Mannich-substitution-acetylation-aldol sequence of reactions.