N. Kalyanam, M. Majeed
Aug 11, 2009
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Journal
ChemInform
Abstract
A readily available γ-glutamyl transfer reagent, namely, N-phthaloyl-L-glutamic anhydride (NPGLA.) offers a simple solution for the raceinization free synthesis of γ-glutamyl amino acids with usefully enhanced properties γ-glutamyi dipeptides (γ-Glu AA) are defined in this context as the compounds derived by the acylation of an amino acid (AA) through the γ-carboxyl carbon of i-glutamic acid. The resulting amide linkage has sometimes been referred as a pseudo-peptide bond. The general structure of a typical γ-glutamyl dipeptide is given in Figure Interest in γ-Glutamyl peptides and analogs is persisted for long (1) The aim of this short review is to highlight the useful improvement of properties of the amino acid which is γ-glutamylated. Also a brief review of the chemistry leading to γ- glutamyl dipeptide in a practical and efficacious way requiring the least number of protection/deprotection steps is presented. Enzymes belonging to the class called γ-glutamyl transpeptidases lead either to the formation of this pseudopeptide bond or the hydrolysis of the γ-glutamyl dipeptide into its constiuent amino acids depending on conditions.