V. Summa, A. Petrocchi, V. Matassa
Sep 16, 2004
Citations
2
Influential Citations
88
Citations
Quality indicators
Journal
Journal of medicinal chemistry
Abstract
A new class of the HCV NS5b RNA-dependent RNA polymerase inhibitors, the dihyroxypyrimidinecarboxylic acid derivative, was designed from a diketoacid and meconic acid derivative discovered by screening. Mechanism of action and essential moieties required for activity were identified. The corresponding N-methylpyrimidinone was also prepared; both classes are novel, reversible, and selective inhibitors of the HCV NS5b polymerase with improved druglike characteristics.