Garib A. Yousif, John D. Roberts
Nov 1, 1968
Citations
0
Influential Citations
20
Citations
Journal
Journal of the American Chemical Society
Abstract
Fluorine magnetic resonance spectroscopy has been used to measure the rates of inversion of 4,4-difluoropiperidine. The activation energy (E_s) was found to be 13.9 and 13.5 kcal/mol in methanol and chloroform, respectively. In acetone, N-H nitrogen inversion was found to be slow on the nmr time scale with an E_s of about 10 kcal/mol. The free-energy difference between the forms with the N-H hydrogen axial and equatorial appears to be 0.42 kcal/mol with uncertain sign.