Liangxi Li, Zhiming Li, Quanrui Wang
Jul 1, 2009
Citations
0
Influential Citations
6
Citations
Journal
Synlett
Abstract
An unprecedented nucleophilic ring opening of cyclopropanecarbaldehydes with benzenethiols proceeds regioselectively under the catalysis of 40 mol% proline to afford fair to good yields of 4-phenylthio-substituted butyraldehydes. If o-thiosalicyl-aldehydes are employed, a tandem homoconjugate addition―aldol reaction occurs, which constitutes an expedient entry to pharmaceutically valuable 2,3-dihydrobenzo[b]thiepine-4-carbaldehydes.