F. Himmelsbach, R. Charubala, W. Pfleiderer
Aug 12, 1987
Citations
0
Influential Citations
9
Citations
Journal
Helvetica Chimica Acta
Abstract
A new, versatile phosphorylating agent, bis[2-(p-nitrophenyl)ethyl] phosphorochloridate (3), has been prepared and is used for 3′- and/or 5′-phosphorylations of nucleosides. The resulting bis[2-(p-nitrophenyl)ethyl] phosphotriesters are versatile synthons in oligonucleotide synthesis leading finally to 3′- and/or 5′-terminated monophosphates in excellent yields.